目的 对中药连翘的酚酸类化学成分进行研究。方法 通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化，根据理化性质和波谱数据进行鉴定。结果 从连翘的体积分数50%乙醇提物中分离得到了16个化合物，分别为丹参素甲酯(1)，原儿茶醛(2)，香草酸(3)，对羟基苯甲酸(4)，对羟基苯甲醇(5)，对羟基苯乙醇(6)，对甲氧基苯乙醛(7)，对羟基苯乙酸(8)，4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate(9)，对香豆酸(10)，对羟基苯基乙酸甲酯(11)，3，4-二羟基苯乙醇(12)，1，2，4-苯三酚(13)，1-(4-羟基苯基)-2，3-二羟基丙酮(14)，对羟基苯甲醛(15)和异香草酸(16)。结论 化合物1～3，5，7，9，11，14为首次从连翘中分离得到。
Abstract
OBJECTIVE To study the chemical constituents from the fruits of Forsythia suspensa (Thunb.) Vahl.. METHODS Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by physiochemical properties and spectral analysis. RESULTS Sixteen compounds were isolated and identified as 3,4,α-trihydroxy-methyl phenylpropionate (1), protocatechaldehyde (2), vanillic acid (3), p-hydroxybenzoic acid (4), p-hydroxylbenzylalcohol (5), p-hydroxyphenylethyl alcohol (6), 2-(4-methoxyphenyl) acetaldehyde (7), 2-(4-hydroxyphenyl)acetic acid (8), 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (9), p-coumatic acid (10), methyl 2-(4-hydroxyphenyl)acetate (11), 3,4-dihydroxyphenylethanol (12), 1,2,4-benzentriol (13), 1-(4-hydroxyphenyl)-2,3-dihydroxypropan-1-one(14), 4-hydroxybenzaldehyde (15), and isovanillic acid (16). CONCLUSION Compounds 1-3, 5, 7, 9, 11, and 14 are isolated from this plant for the first time.
关键词
连翘 /
酚酸类 /
结构鉴定 /
原儿茶醛 /
香草酸 /
对羟基苯甲醇 /
对甲氧基苯乙醛
{{custom_keyword}} /
Key words
Forsythia suspensa(Thunb.) Vahl. /
phenolic acid /
structural identification /
protocatechaldehyde /
vanillic acid /
p-hydroxylbenzylalcohol /
2-(4-methoxyphenyl) acetaldehyde
{{custom_keyword}} /
中图分类号：
R284
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Editorial Committee of Flora of China. Flora of China (中国植物志) . Beijing: Science Press, 1992, 61: 42.
[2] YAN X J, BAI X Y, LIU Q B, et al. Two new glycosides from the fruits of Forsythia suspense . J Asia Nat Prod Res, 2014, 16(4):376-382.
[3] YAN X J, PENG Y, LIU Z X, et al. Three new lignan glycosides from the fruits of Forsythia suspense. J Asia Nat Prod Res, 2014, 16(6):602-610.
[4] WANG Y, YE W C, YIN Z Q, et al. Triterpene saponins from Adinandra nitida . Acta Pharm Sin (药学学报), 2008,43(5):504-508.
[5] HE J, MA B Z, ZHAO T, et al. Chemical constituents from the roots of Actinidia chinensis. Chin Pharm J (中国药学杂志), 2014, 49(3):184-186.
[6] FENG W S, WANG J C, HE Y H, et al. Chemical constituents from the flower buds of Magnolia biondii Pamp. . Chin Pharm J (中国药学杂志), 2015, 50(24):2103-2106.
[7] HE J, CHEN Z, YANG Y N, et al. Chemical constituents from aqueous extract of Carthamus tinctorius . Chin Pharm J (中国药学杂志), 2014, 49(6):455-458.
[8] WANG Y N, LIN S, CHEN M H, et al. Chemical constituents from aqueous extract of Gastrodia elata . J Agric Food Chem, 2012, 47(12):1775-1781.
[9] ZHANG Y L, FENG Z Y, ZHENG X K, et al. Chemical constituents from the leaves of Rehmannia glutinosa Libosch . Chin Pharm J (中国药学杂志), 2014,49(1):15-21.
AMARBNDRA P, PRABIR K, MUKHOPADHYAY C, et al. Carbon-13NMR spectra of some benzene derivatives . J Indian Chem Soc,1983, 21(3):265-268.
WANG Y N, TIAN L, HUA H M, et al. Two new compounds from the broth of the marine fungus penicillium griseofulvum Y19-07 . J Asian Nat Prod Res, 2009, 11(11):912-917.
YAO J Q, MENG N, SONG S J, et al. Chemical constituents from the Portulaca oleracea L. . J Shenyang Pharm Univ (沈阳药科大学学报), 2007,24(12):751-753.
LI C Y, GAO H, JIAO W H, et al. Isolation and identification of quinones constituents from root cortex of Morinda officeinalis How . J Shenyang Pharm Univ (沈阳药科大学学报), 2011, 28(1):30-36.
HELENE T, SERGE F, NGADJUI B T, et al. Phenolic metabolites from the seeds of Canarium schweinfurthii. Bull Chem Soc Ethiopia, 2000,14(2):70-76.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
2016年哈尔滨商业大学研究团队支持项目(批准号:2016TD009);2016年哈尔滨商业大学静创新人才支持项目(批准号:2016QN074)
{{custom_fund}}
PDF(1060 KB)
